This variant is located downstream of CDH2 (OMIM 114020), which encodes N-cadherin and has been shown to play a role in the development of the nervous system and be associated with neurodevelopmental disorders.44 The third locus is 22q13.31 with lead variant rs12160976 (β for A allele = −0.009, SE = 0.002, P = 1.6 × 10−8). This evidence concerns the gene CDH2 and neurodevelopmental disorder.