Thus, apart from blood glucose control, intensive blood pressure lowering and active use of renin-angiotensin system blockers and sodium-glucose cotransporter 2 inhibitors should be considered in treatment of patients with albuminuria.20,21,22,23 However, among patients with diabetes and CKD but no albuminuria, deliberate glycemic control may still be important to decrease overall health risks. The gene discussed is REN; the disease is diabetes mellitus.