BDNF and neuropathic pain: Activation of the kinase receptor triggers intracellular signals that provide neuroplasticity effects, and germination of sensory fibers.(29,30) In addition, sprouting fibers with various sensitive functionalities lead to development of paresthesia, allodynia and hyperpathia.(28,30) Thus, BDNF-TrkB signaling is involved in the development of neuropathic pain in DPN, and is responsible for hyperalgesia effects and transformation of nociceptive pain into neuropathic pain.