On the one hand, increased expression of BDNF as well as mutations in BDNF or TrkB gene are associated to obesity conditions.(11) On the other hand, some research showed high positive correlations among serum levels of BDNF and body mass index (BMI), percentage of body fat, triglyceride and fasting glucose levels.(12) An animal model experiment demonstrated mechanical, thermal, inflammatory nociception was reduced in the group of animals deprived of food, which correlated with reduced production of CREB, ERK and mTOR proteins in the dorsal spinal ganglion and spinal cord.(13,14). The gene discussed is NTRK2; the disease is obesity due to melanocortin 4 receptor deficiency.