The apolipoprotein E4 (APOE4) allele is considered a major shared risk factor for both cardiovascular disease (CVD) (Hansson and Libby, 2006) and Alzheimer’s disease (AD) (Belloy et al., 2019; Smith et al., 2019), in part due to its role in lipid metabolism and related inflammation (Huebbe and Rimbach, 2017). This evidence concerns the gene APOE and early-onset autosomal dominant Alzheimer disease.