Based upon the clinical and immunoinflammatory outcomes of the present study, it is anticipated that in patients with peri-implant mucositis, increasing PD correlates with the expression of IL-1β and suPAR in the PISF, which in turn increases the PISF galectin-1 levels to repulse the peri-implant inflammatory burden. This evidence concerns the gene LGALS1 and mucositis.