In various in vitro and animal models, the main constituents M6PR (mannose 6-phosphate receptor), CA (calcium), GPx (glutathione peroxidase), and SOD (superoxide dismutase) in AV proved to have strong anti-inflammatory, anti-microbial and anti-oxidant effects.18 Thus, in our study, AV gel effectively helped reduce gingival bleeding. Here, SOD1 is linked to Gingival bleeding.