In our cohort, soluble EC activation biomarkers (e.g. ICAM-1, VCAM-1, E-selectin, Ang-2, CD40L, vWF-A2) and the EC damage product, Syndecan-1, are positively correlated with thrombocytopenia, lymphopenia, anaemia, and neutrophil enrichment in the peripheral blood. The gene discussed is CD40LG; the disease is Thrombocytopenia.