NKG2D ligands‐targeted CAR‐T cells efficiently lysed glioblastoma cells and cancer stem cells in vitro and produced high levels of cytokines, perforin and granzyme B. In vivo, the CAR‐T cells markedly eliminated xenograft tumours and did not exhibit significant toxicity in the treated mice47. The gene discussed is PRF1; the disease is glioblastoma.