Patients' HER2‐specific CAR‐T cells killed CD133‐positive and CD133‐negative cells derived from primary HER2‐positive glioblastomas. These HER2‐specific T cells had a potent antitumor activity against autologous tumours in an orthotopic xenogeneic SCID mouse model48. The gene discussed is PROM1; the disease is glioblastoma.