Interestingly, deletion or inhibition of S1PL in adult mice suppresses osteoclastogenesis and stimulates osteobalstogenesis, thereby phenocopying the high‐bone‐mass phenotype observed in newborn global Sgpl1‐knockout mice, as well as successfully rescuing severe genetic osteoporosis caused by osteoprotegerin deficiency (Weske et al., 2018, 2019). The gene discussed is SGPL1; the disease is osteoporosis.