TIMP1 and heart disorder: Therefore, the ECM composition can affect both cell function and further ECM generation.3 For examining the effect of LMNA mutation on probable ECM composition, the scRNA-seq30 data were compared between patient and control cells for the expression of ECM proteins known to be indicative of heart disease.9 Twelve ECM genes from the family TIMP, MMP, and COL#A1 were found to be overexpressed in patient cells indicating possible essential consequences of the mutation (example shown in Fig. 3, all provided in Supplemental Data File 3).