PAGR1 and cardiomyopathy: Alternatively, overexpression of TMOD1 can lead to degeneration of the myofibrils, which is associated with some clinical presentations of cardiomyopathies.40 It is important to note that many cells in the patient populations have the same expression level of TMOD1 as the control cells, but there are more cells with a higher expression in PA1 leading to the higher average expression [Fig. 4a(i)].