Although no signs of malnutrition were detected in the laboratory test results at presentation (serum albumin: 3.8 g/dL, total protein 7.3 g/dL, lymphocyte counts: 1500/μL; all were at normal level), the patient showed weight loss of 10% during the past one year; since it was considered to indicate malnutrition, we performed active nutrition therapy from the time of admission. The gene discussed is ALB; the disease is nutritional deficiency disease.