For the first instance of gemcitabine and using Score1, we observed (Figure 1B) that it, as intended, reversed many enriched pathways (ACPs) in the PANC-1 pancreatic cancer cell line, including (using NCBI BioSystems(Geer et al., 2010) annotations) PLK1 signaling events, Resolution of Sister Chromatid Cohesion, Kinesins, Cell Cycle, Phosphorylation of Emi 1, and the Hedgehog Signaling Pathway (Figure 2A; Table S1). Here, PLK1 is linked to pancreatic neoplasm.