Among individuals who met Medicare criteria, P/LP variants were identified in polyposis genes (BMPR1A, SMAD4, PTEN, and APC), whereas, among those who did not meet criteria, a larger proportion of variants were identified in ATM, STK11, and monoallelic or biallelic MUTYH. Reasons for these differences could be related to higher rates of family history of CRC and endometrial cancers among individuals who met criteria compared with those who did not meet criteria, although this could not be evaluated on the basis of lack of granular family history in this data set. The gene discussed is APC; the disease is endometrial cancer.