MXD3 and malignant colon neoplasm: At the same time, analysis of gene-knockout phenotypes from genetic screens revealed that MXD3-knockout was a strong influencer of lymphocyte-mediated tumor killing in MC38 colon cancer (Kearney2018_NK_20) and K562 leukemia (Pech2019_NK_E:T = 2.5) models (Fig. 4D).