We found that mRNA levels of MXD3 were expressed in a deregulated manner in almost all TCGA cancer types and were correlated with tumor staging or metastasis of ACC, KICH, KIRC, KIRP, LICH, SKCMC of PCPG, HNSC, THCA, BRCA, and CESC; these findings suggested that MXD3 is an oncogenic molecule of tumor progression, invasion, and metastasis. Here, MXD3 is linked to adrenal cortex carcinoma.