MXD3 and acute lymphoblastic leukemia: In accordance with our observations, previous studies reported that MXD3-knockdown resulted in apoptosis of neuroblastoma cells and enhanced the therapeutic efficacy of chemotherapies against a neuroblastoma cell line [54] while knocking down/target deletion of MXD3 induced apoptosis of Reh human precursor B acute lymphoblastic leukemia cells [54] and sensitized neuronal and lymphoid cells to radiation-induced apoptosis [74].