Based on NSM activity as a biomarker signal for alcoholism, we tested for the associations of single nucleotide polymorphisms in the NSM-2 coding gene SMPD3 with alcohol use in a population of 456,693 participants (56% female) with complete genotype and behavioural data from the UK Biobank, a large cohort of United Kingdom residents aged 40–69 years [9] (Table S1). The gene discussed is SMPD3; the disease is alcohol dependence.