We furthered our study performing an RNA-Seq analysis of 37 CRPC MDA PCa PDXs, [16, 18] focusing on AR and AR downstream targets’ gene expression (ERG, TMPRSS2, KLK3, CAMKK2, NKX3.1, FKBP5, PGC, PMEPA1). This evidence concerns the gene NKX3-1 and posterior cortical atrophy.