ACAT1 and posterior cortical atrophy: Most importantly, when we studied the expression of ACAT1, OXCT1, and BDH1 in the human donor tumor of MDA PCa 183, we detected significant increased expression of these enzymes in PCa progressing to ADT as compared with the untreated tumor of the same patient (Fig. 5D, E, P < 0.0001, P < 0.0001, P = 0.0033, respectively).