ACAT1 was proposed as a druggable target for cancer therapy since in its active phosphorylated tetrameric form, catalyzes the conversion of two acetyl-CoA to acetoacetyl-CoA and CoA and also acts as an upstream acetyl transferase for the pyruvate dehydrogenase complex, a decisive point between two paths: glycolysis and oxidative phosphorylation [40]. Here, ACAT1 is linked to cancer.