Considering the powerful effect to complete remissions by activating an endogenous CD8 T cell and NK cell-mediated immune response upon transient Treg depletion in our independent genetic models in MM bearing mice, emphasizes that strategies to target Tregs more selectively are desperately needed, and existing strategies must be reevaluated regarding the local bioavailability and depletion efficiency in the BM. Here, CD8A is linked to Miyoshi myopathy.