CD3+CD4+CD25++FoxP3+ regulatory T cells (0.8% ± 0.8 vs. 2.6% ± 1.2 of CD3+ T cells, p < 0.01) and CD4+CD45RA−CXCR5+ T follicular helper cells as major CD4+ T cells subsets were also significantly lower in HL patients (0.6% ± 0.8 vs. 2.9% ± 2.1, p < 0.01). Here, CD4 is linked to Hodgkins lymphoma.