PRKAA1 and colorectal carcinoma: Accordingly, we next examined the effects of doxorubicin and melatonin on AMPKα1 levels in other cancer cell lines, including hepatocellular carcinoma (HepG2, Huh7), colorectal carcinoma (HCT116), lung adenocarcinoma (A549), and gastric adenocarcinoma (AGS) cell lines.