APP and Alzheimer disease: Several other miRNAs also target key proteins in AD, like miR-106a, miR-106b, miR-520c, miR-101 and miR-153 directly target Amyloid Precursor Protein and control Aβ levels; miR-29a/b/c, miR-107, miR-195 and miR-124 targets BACE1, thereby regulating the intramembrane cleavage of APP; miR-132 targets Tau; miR-34a targets TREM2 and miR-146a targets a critical component of actin modulator, ROCK122.