Concerning schizophrenia, a meta-analysis reported increased levels of IFN-γ, IL-1RA, IL-1β, IL-6, IL-8, IL-12, sIL-2R, TGF-β and TNF-α in acutely ill patients (i.e. acutely psychotic) with chronic schizophrenia and a significant decrease in IL-1β, IL-4 and IL-6 following treatment25. This evidence concerns the gene IL6 and schizophrenia.