However, a recent large meta-analysis revealed a consistent elevation of inflammatory markers in MDD, among them CRP, IL-3, IL-6, IL-12, IL-18, sIL-2R and TNF-α28 and a study assessing 43 meta-analyses reported increased levels of inflammatory markers, including CRP, IL-6, IL12 in both MDD and SZ26. Here, IL18 is linked to major depressive disorder.