In the clinicopathological analysis, high OSBPL3 expression was significantly associated with the depth of tumor invasion, lymph node metastasis, stage III/IV, well or moderately differentiated adenocarcinoma, and age (Fisher’s exact test, p < 0.05) based on the GSE15459 dataset (Supplementary Table S3). The gene discussed is OSBPL3; the disease is adenocarcinoma.