Our principal findings included associations between (1) nonsynonymous rare variants in PARK2 and the FTD cohort; (2) nonsynonymous rare variants in NOTCH3 and the PD cohort; (3) rare, putative LOF variants in PD-associated genes across the entire ONDRI cohort; and (4) rare, putative LOF variants in ALS/FTD-associated genes in the ALS and MCI cohorts. The gene discussed is PRKN; the disease is Parkinson disease.