Firth logistic regression, which was used to accommodate for the limitations of SKAT-O, revealed significant differences in nonsynonymous rare variant enrichment in three genes in the ONDRI cohorts compared to the controls (Table 3), including CHMP2B across the combined neurodegenerative disease ONDRI cohort (OR = 0.080, p = 0.0008), NEFH in the CVD cohort (OR = 0.360, p = 0.036), and PARK2 in the FTD cohort (OR = 11.602, p = 0.023). This evidence concerns the gene CHMP2B and frontotemporal dementia.