When we examined the individual genes that contributed to the association, 8 of the 13 putative LOF PD-associated variant-positive participants (61.5%) harboured variants in MC1R. Specifically, the putative LOF variants in MC1R were identified in the CVD, FTD, MCI, and PD cohorts, as well as in one control participant. Here, MC1R is linked to Parkinson disease.