Besides inv(3)/t(3;3), many other EVI1 + AML cases with 3q26 rearrangements have been reported, including translocations t(2;3)(p21;q26), t(3;7)(q26;q24), t(3;6)(q26;q11), and t(3;8)(q26;q24)18,20–27. The gene discussed is MECOM; the disease is acute myeloid leukemia.