Well-described examples are the inv(3)(q21q26) or t(3;3)(q21;q26) rearrangements in acute myeloid leukemia (inv(3)/t(3;3) AML), in which a GATA2 enhancer at 3q21 is hijacked by EVI1 at 3q26, causing EVI1 overexpression and GATA2 haploinsufficiency14,15. The gene discussed is RUNX1; the disease is acute myeloid leukemia.