The loci donating their enhancer to EVI1 harbor genes that are normally expressed in early HSPCs, e.g., MYC, ARID1B, CDK6, THADA, or GATA2. Leukemias with high EVI1 levels are chemotherapy-resistant and exhibit a unique gene expression signature comparable to that of CD34 + HSPCs32. Here, CDK6 is linked to leukemia.