Comparison of the expression of these genes between MPT0B291-treated samples and patients with GBM revealed a negative correlation (Pearson’s r = −0.412) (Supplementary Fig. S1B), indicating that inhibition of HDAC6 by MPT0B291 has a potential to reverse the abnormalities of DDR genes in GBM. Here, HDAC6 is linked to glioblastoma.