EGFR and glioblastoma: In addition to the epidermal growth factor receptor (EGFR) gene, i.e., the proto-oncogene most commonly amplified and overexpressed in IDH-wildtype glioblastoma [9], HOTAIRM1 and the protein-coding gene MEOX2 showed consistently increased expression in tumors with chromosome 7 gain when compared to tumors without this copy number increase (Fig. 1G, H).