HOTAIRM1 and central nervous system cancer: To characterize molecular mechanisms underlying the observed effects of HOTAIRM1 knock-down on glioma cells in vitro, we performed RNA sequencing and MS-based proteome analyses on three siRNA-mediated HOTAIRM1 knock-down models (U251, LN-229, and T98G) and their respective control-transfected cell lines (Supplementary Tables 2-3).