The MVMR OR for overall breast cancer per SD increase in IGF-I, conditioned on LDL-C, HDL-C, and TG, was 1.09 (95% CI, 1.05–1.14; P = 0.0001; Table 5), which was comparable to the lipid unadjusted model (OR = 1.09; 95% CI, 1.04–1.15; P = 0.001; Table 2). Here, IGF1 is linked to breast cancer.