Using data from BCAC, the MVMR OR for overall breast cancer per SD increase in TG, conditioned on HDL-C, LDL-C, and IGF-I, was 0.95 (95% CI, 0.92–0.99; P = 0.03; Table 5), which was comparable with the IGF-I unadjusted model (OR = 0.95; 95% CI, 0.91–0.99; P = 0.01; Fig. 2). This evidence concerns the gene IGF1 and breast cancer.