PINK1 and Parkinson disease: Additionally, we previously determined that inhibiting atfs-1 in long-lived nuo-6 worms completely suppressed the increased resistance to oxidative stress, osmotic stress, and heat stress typically observed in that mutant (Wu et al, 2018) and that disruption of atfs-1 in Parkinson’s disease mutants pdr-1 and pink-1 decreased their resistance to oxidative stress, osmotic stress, heat stress, and anoxia (Cooper et al, 2017).