ANXA11 and chronic obstructive pulmonary disease: Of the DMRs found to be differentially methylated in vapers compared with both smokers and non-smokers, ANXA11 suggestively plays an important role in lung function, and variation in this gene has been associated with Sarcoidosis (mainly affecting the lung) [45] and Chronic Obstructive Pulmonary Disease-related biomarkers [46].