Several of these compounds have entered clinical trials, including APR-246 (eprenetapopt) in combination with azacytidine for myelodysplastic syndromes (MDS) with mutp53, which demonstrated a significantly higher rate of complete remission (CR) in patients with only TP53 mutation (NCT 03072043) [48]. The gene discussed is TP53; the disease is myelodysplastic syndrome.