TXNIP and neoplasm: By contrast, we discovered six genes to be downregulated in all patients in plaque/tumor vs. patch lesions, namely the chemokine receptor CXCR4, the skin residency marker CD69, the heat shock protein HSPA1A, the anti-inflammatory mediator tristetraprolin (i.e. zinc finger protein 36 homolog ZFP36), the interleukin-7 receptor IL7R, and the thioredoxin-interacting protein TXNIP (Fig. 3 H, Table S3).