A larger population of COL1A2+ fibroblasts contained five clusters (FB-1: COL1A1, MFAP5, FBN1-positive cells constituting the largest group [20]; FB-2: CCL19, CXCL9; FB-3: POSTN, CCL2, COL6A5, COL18A1 and CCL19 cells previously described as inflammatory fibroblasts in AD [21]; FB-4: APOD, CFD, APOE, CXCL12; and FB-5: COL1A1, SPARC; Fig. 1 C, Fig. S1C-D, Table S2). This evidence concerns the gene SPARC and Alzheimer disease.