Nevertheless, the fact that CXCR4, CD69, HSPA1A, ZFP36, IL7R and TXNIP were concomitantly decreased in TCR-αβ and TCR-γδ tumor cells of advanced MF lesions, and the observation that CD69, HSPA1A and ZFP36 were increased in early-stage MF patients, suggests that this marker panel reflects a general mechanism of skin lesion progression in MF in a continuous fashion from longstanding indolent to more aggressive late-stage disease. This evidence concerns the gene CD69 and neoplasm.