When calculating DEGs in plaque vs. patch lesions, we again found most DEGs to be present in monoclonal γδ T cell clusters (Fig. 5 F, Table S6-S7), that included cytotoxic markers such as GZMA, NKG7, GZMK, GZMB, CTSW, TYROBP (DAP12), and GZMH, but also the coiled-coil domain containing 85B (CCDC85B) previously associated with cancer proliferation and invasion [30], and the actin-binding PFN1 (Profilin-1) (Fig. 5 G, Table S6). Here, PFN1 is linked to cancer.