Genes that were present at significantly higher levels in malignant cells of patches from advanced vs. early-stage MF included the lymph node homing markers CCR7, SELL and CD27 [31], the CTCL markers IGFL2 and KIR3DL2 [32, 33], the helper T cell growth factor IL16 that has previously been implicated in recruitment of malignant cells to MF lesions [34], and the lymphocyte developmental marker IKZF2 [35] (Fig. 6 F). This evidence concerns the gene IKZF2 and mycosis fungoides.