GGT can mediate the production of ROS, promote cell growth and proliferation [29] and is often elevated in liver diseases such as hepatitis, cancer and vascular invasion [25, 26, 30].ALT is also known as a marker of liver dysfunction and inflammation, which was found to be associated with recurrence and poor survival of HBV-related HCC [31, 32]. This evidence concerns the gene GPT and hepatitis A virus infection.