GLP-1Ra mimic the “incretin” effect on weight loss and blood pressure (the latter mostly due to afterload reduction and natriuresis [12]); the infusion of exenatide for 6 h in 20 subjects with T2D and decompensated HFrEF induced a small decrease in pulmonary capillary wedge pressure (14.8 to 12.6 mmHg) and an increase in cardiac output from 1.8 to 2.1 L/min, largely due to an increase in heart rate, without affecting NT-proBNP levels [13]. The gene discussed is NPPB; the disease is type 2 diabetes mellitus.