Because the activation of the NLRP3 inflammasome could induce the overproduction of IL-1β, resulting in inflammation and arthritis, we evaluated the expression of NLRP3, caspase-1 p20 (a functional caspase-1 subunit) and IL-1β in the ankle joint synovial tissue by Western blot. The gene discussed is IL1B; the disease is Arthritis.