CRP is a homopentameric acute-phase inflammatory protein, which reacts with the capsular (C)-polysaccharide of Pneumococcus. In the presence of calcium, CRP binds to polysaccharides such as phosphocholine on microorganisms and triggers the classical complement pathway of innate immunity by activating C1q and can respond quickly to bacterial infection [13]. The gene discussed is CRP; the disease is bacterial infectious disease.