For example, in the context of TAMs supporting stemness in colorectal cancer, the most prominent pathway is SHH (Jinushi et al. 2011), in pancreatic cancer is the TGFβ/ SMAD2/3/NANOG (Zhang et al. 2019b), and in hepatocarcinoma is the NOTCH pathway (Yang et al. 2013; Wang et al. 2016). Here, NANOG is linked to familial pancreatic carcinoma.