IL33 and cancer: Its role in tumors is under debate; in fact, on the one hand IL-33 can promote T cell antitumor activity (Villarreal et al. 2014; Gao et al. 2015), on the other, its expression has been associated with metastasis in several cancer models (Jovanovic et al. 2014; Gillibert-Duplantier et al. 2012; Liu et al. 2014) and, accordingly, it is under study as a therapeutic target (Sun et al. 2021).