IL6 and neoplasm: For instance, the cytokines IL-6 and IL-10 activate the transcription factor STAT3, which inhibits in macrophages the genes encoding for anti-tumor cytokines (Raghavan et al. 2019; Wyckoff et al. 2004; Wu et al. 2010; Kobatake et al. 2020; Gabrusiewicz et al. 2018).