H19 and osteoporosis: In addition, studies have found that H19 mediates estrogen-regulated osteogenic differentiation in BMSCs through the miR-532-3p/SIRT1 axis, and estrogen can mediate miR-532-3p/SIRT1 axis to reduce osteoporosis in ovariectomy rats by up-regulating H19 (Li et al. 2021).