TGFBR2 and Loeys-Dietz syndrome: According to some finds, there are multiple genetic syndromes associated with aortic aneurysmal disease, such as Marfan syndrome (FBN1), Ehlers-Danlos syndrome (COL5A1, COL5A2, COL3A1), Loeys-Dietz syndrome (TGFBR1, TGFBR2), FTAAD (TGFBR2, MYH1, ACTA2), and autosomal dominant polycystic kidney disease (PDK1, PKD2) [53].