POMT2 and muscular dystrophy-dystroglycanopathy, type A: Mutations in these enzymes can cause autosomal recessive limb-girdle muscular dystrophies, LGMD2 K and LGMD2N [36], or severe Walker–Warburg syndrome (WWS), which is an autosomal recessive condition characterized by congenital muscular dystrophy, structural brain defects and eye malformations [34,35].