Moreover, more detailed data analysis showed that ANGPTL8 was significantly correlated with insulin resistance [9,29], fasting blood glucose [35], postprandial blood glucose [36] and glycosylated haemoglobin (HbA1c) [37], which theoretically supported the association between ANGPTL8 and T2DM. This evidence concerns the gene ANGPTL8 and type 2 diabetes mellitus.