ANGPTL8 and obesity due to melanocortin 4 receptor deficiency: Li et al. found that although circulating ANGPTL8 as well as mRNA in liver, WAT and brown adipose tissue (BAT) were significantly increased in T2DM models (diet-induced-obesity (DIO) mice and db/db mice), circulating ANGPTL8 and mRNA in tissues of T1DM models (C57B6 mice receiving streptozotocin (STZ) and 70% pancreatectomy to destroy or remove β-cells) were decreased, respectively [41].