Although GDM is accompanied by the increase of circulating ANGPTL8 level [57], and ANGPTL8 is also considered as a molecular marker for early prediction and prognosis of GDM [58,59], but during normal pregnancy, the circulating ANGPTL8 concentration decreases continuously even if insulin resistance and TG levels increase with the progress of pregnancy [60]. The gene discussed is INS; the disease is gestational diabetes.