A study done on HCC cells demonstrated that miR-142-3p sensitised cells to sorafenib by promoting apoptosis and inhibiting cell growth and proliferation via targeting autophagy related 5 (ATG5) and autophagy-related 16-like 1 (ATG16L1) which are the main targets of autophagy regulating miR-142-3p (Zhang et al., 2018). This evidence concerns the gene ATG16L1 and hepatocellular carcinoma.