The HBV immunization is strongly recommended for cancer patients ngative for HBsAg, and anti-HBc undergoping chemotherapy (Ariza-Heredia et al., 2015) The HBV vaccine response rate was found more than 70% of cancer patients receiving chemotherapy (Weitberg et al., 1985), In this study, none of cancer patients have received HBV vaccine. Here, KRT88P is linked to cancer.