These results indicate that the overexpression of the three protein targets of diosmin and PGV-1, namely CDK1, KIF11, and AURKA, has an adverse effect on the survival of breast cancer patients so that these three targets are essential in breast cancer, especially the TNBC type breast cancer that does not have an expression of HER, ER, and PR target receptors. The gene discussed is ESR1; the disease is breast cancer.