For the standard anti-cancer 5-FU treatment, its induction of apoptosis was significantly less than our combinational therapy with TQ+TRAIL, where it we observed a significant enhancement of apoptosis (p less than 0.01) of MDA-MB-231 cells treated with 5-FU (55.0 % apoptosis versus 9.45 % of the untreated control) compared with the individual treatments with TRAIL and TQ (Figure 2). This evidence concerns the gene TNFSF10 and cancer.