BCL2 and neoplasm: Remarkably, up-regulation of DR4, DR5 and pro-apoptotic genes, as well as down-regulation of the anti-apoptotic B-cell lymphoma 2 (Bcl-2) gene and inhibitors of apoptosis in TRAIL-resistant tumor cell lines correlated with sensitization to TRAIL-induced apoptosis (Singh et al., 2003; Poulain et al., 2009), which in-line with our genetic profiling results.