The synergistic effect of the combination therapy of TQ and TRAIL significantly inhibit the genetic expressions of Bcl2 gene and upregulate the genetic expressions of Cas-8 and FADD genes up on breast cancer MCF-7 and MDA-MB-231 cell lines treated for 24 h with noted TQ or/and TRAIL concentrations. The gene discussed is BCL2; the disease is breast carcinoma.