It was suggested that transformed LGR5-positive stem cells are the origin of cancer in the intestine (Hsu et al., 2013; Yui et al.; 2012).Therefore, LGR5 was proposed as an ideal marker for CSCs in CRC (Kemper et al., 2012; Hirsch et al., 2014). This evidence concerns the gene LGR5 and colorectal carcinoma.