LGR5 and colorectal carcinoma: (Uchida et al., 2010; He et al., 2014; Kleist et al., 2011; Hsu et al., 2013) Overexpression of LGR5 in CRC maybe attributed to enrichment of ‘stem-like’ cancer cells, upregulation of the Wnt signaling pathway and/or Wnt -dependent maintenance of stemness (Uchida et al., 2010, Walker et al., 2011).