LGR5 and colorectal carcinoma: The studies, detected the LGR5 using in situ hybridization in CRC, have found different results; same of them have shown correlation between LGR5 upregulation and poor prognosis (Baker et al.,2015; Uchida et al., 2010) while others did not find any association (Ziskin et al., 2013; Jang et al., 2018).