STAT3 and cardiac hypertrophy: (Figure 6A) The quantitative analysis of relative protein levels further confirmed that orexin B significantly reduced increased levels of type I and III collagen, IL6, p-STAT3, and TGF-β in fibroblasts transfected with miR-320 mimic (Figure 6B, P < 0.05), suggesting that PTEN was involved in the miR-320 mimics-induced development of cardiac hypertrophy and fibrosis.