APOE and Alzheimer disease: Additionally, there was a significant three-way interaction of systolic BPV by APOE ε4 carrier status by time on hippocampal (ß: -1.89 [95% CI -2.44, -1.31]) and entorhinal cortex (ß: -1.36 [95% CI -2.04, -0.11]) volume, indicating that volumetric change at follow-up was related to elevated systolic BPV specifically in APOE ε4 carriers with AD pathophysiology (Fig. 2b).