GHRL and obesity due to melanocortin 4 receptor deficiency: Although we found a significant BMI status by drink interaction on AUC for acyl-ghrelin (P for interaction = .03), stratified analyses revealed that individuals with healthy weight (β, –8716.14; 95% CI, –11139.00 to –6293.65; P < .001), overweight (β, –6046.44; 95% CI, –8580.14 to –3512.74; P < .001), and obesity (β, –3466.44; 95% CI, −4824.76 to −2108.13; P < .001) all had significantly greater suppression of acyl-ghrelin after sucrose compared with sucralose ingestion (eFigure 4 in Supplement 2).