GATA3 and colitis: In addition, despite the primarily role of TH1 immune responses in the establishment of ileitis in SAMP1/YitFc mice, the terminal ileal tissue manifested an elevated type 2 immunity signature (IL-5, IL-13, and GATA3/Tbet ratio) during chronic inflammation compared with the healthy control [23].TH2 responses are also the driving force in an oxazolone-induced colitis murine model, which can be attenuated by suppressing type 2 cytokines [24–26].