After these analyses, we focused our attention on OAS1 because its antiviral activity was the most robust (Fig. 2, A to C), its low basal transcription was highly IFN inducible (Fig. 2, D and E), its mRNA was readily detectable in infected patients (Fig. 2F), and common allelic variants were associated with altered susceptibility to infection and severe disease (Fig. 2G) (1, 22, 24, 25). Here, OAS1 is linked to infection.